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A germ layer, primary germinal layer, or germinal layer is a primary layer of cells that forms during animal embryonic development. Germ layers form during gastrulation, when the early embryo is formed of two or three layers of cells.
do not have a gastrulation stage and possess no true germ layers. They do though have two layers of cells separated by a gel-like mesohyl. Some aquatic such as , and comb jellies, develop from only two germ layers, an ectoderm and an endoderm, and are known as . But most animals have a bilateral symmetry, and develop from three germ layers, an ectoderm, endoderm, and a middle layer of mesoderm, and are triploblastic.
Germ layers eventually give rise to all of an animal's tissues and organs through the processes of histogenesis, and organogenesis.
In the human embryo, after about three days, the zygote forms a solid mass of cells by mitotic division, called a morula. This then changes to a blastocyst, consisting of an outer layer called a trophoblast, and an inner cell mass called the embryoblast. Filled with uterine fluid, the blastocyst breaks out of the zona pellucida and undergoes implantation. The inner cell mass initially has two layers: the hypoblast and epiblast. At the end of the second week, a primitive streak appears. The epiblast in this region moves towards the primitive streak, dives down into it, and forms a new layer, called the endoderm, pushing the hypoblast out of the way (this goes on to form the amnion.) The epiblast keeps moving and forms a second layer, the mesoderm. The top layer is now called the ectoderm.
Gastrulation occurs in reference to the primary body axis. Germ layer formation is linked to the primary body axis as well, however it is less reliant on it than gastrulation is. Hydractinia shows that germ layer formation that transpires as a mixed delamination.
In mice, germ layer differentiation is controlled by two transcription factors: Sox2 and Oct4 proteins. These transcription factors cause the pluripotent mouse embryonic stem cells to select a germ layer fate. Sox2 promotes ectodermal differentiation, while Oct4 promotes mesendodermal differentiation. Each gene inhibits what the other promotes. Amounts of each protein are different throughout the genome, causing the embryonic stem cells to select their fate.
The endoderm consists at first of flattened cells, which subsequently become columnar. It forms the epithelial lining of the whole of the digestive tract except part of the mouth and pharynx and the terminal part of the rectum (which are lined by involutions of the ectoderm). It also forms the lining cells of all the glands which open into the digestive tract, including those of the liver and pancreas; the epithelium of the auditory tube and tympanic cavity; the trachea, bronchi, and alveoli of the lungs; the bladder and part of the urethra; and the follicle lining of the thyroid gland and thymus.
The endoderm forms: the pharynx, the esophagus, the stomach, the small intestine, the large intestine, the liver, the pancreas, the urinary bladder, the epithelial parts of the trachea and bronchi, the lungs, the thyroid, and the parathyroid.
The mesoderm has several components which develop into tissues: axial mesoderm, intermediate mesoderm, paraxial mesoderm, and lateral plate mesoderm. The axial mesoderm develops into the notochord. The intermediate mesoderm develops into kidneys and gonads. The paraxial mesoderm develops into cartilage, skeletal muscle, and dermis. The lateral plate mesoderm develops into the circulatory system (including the heart and spleen), the wall of the gut, and wall of the human body.
Through cell signaling cascades and interactions with the ectodermal and endodermal cells, the mesodermal cells begin the process of differentiation.
The mesoderm forms: muscle (smooth and striated), bone, cartilage, connective tissue, adipose tissue, circulatory system, lymphatic system, dermis, dentine of teeth, genitourinary system, , spleen and notochord.
The surface ectoderm develops into: epidermis, hair, nails, lens of the eye, sebaceous glands, cornea, tooth enamel, the epithelium of the mouth and nose.
The neural crest of the ectoderm develops into: peripheral nervous system, adrenal medulla, melanocytes, facial cartilage.
The neural tube of the ectoderm develops into: brain, spinal cord, posterior pituitary, motor neurons, retina.
Note: The anterior pituitary develops from the ectodermal tissue of Rathke's pouch.
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